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KMID : 1039620210110020142
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Korean Journal of Family Practice
2021 Volume.11 No. 2 p.142 ~ p.146
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Recent Trends in Opioid Prescription in Cancer Patients in Korea
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Yoon Ji-Hyun
Kim Hyeong-Seop
Lee Jae-Woo
Kim Joung-Youn
Kang Hee-Taik
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Abstract
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Background: This study aimed to estimate the trends in opioid prescriptions for pain control in patients with and without cancer between 2002 and 2015.
Methods: This retrospective study was based on data from the 2002 and 2015 Korean National Health Insurance Service-National Health Screening Cohort Study. Prescriptions of commonly used opioids, including morphine, oxycodone, fentanyl, and hydromorphone, were included in this study. A joinpoint regression analysis was adopted to analyze significant changes in the trends of annual opioid prescriptions, specifically considering the annual percentage change (APC) and average APC (AAPC).
Results: The proportion of cancer patients to the total number of opioid prescriptions increased significantly, from 0.18/10,000 registrants in 2002 to 62.27/10,000 registrants, increasing with an AAPC of 62.3% (95% confidence interval [CI], 44.7?82.1, P<0.05) during this study. The annual prescription rate also increased by 49.9% (95% CI, 22.6?83.2, P<0.05) in the non-cancer groups over the study period. In particular, there was a dramatic increase in prescriptions from 2006 to 2009, with an APC of 230.2% (95% CI, 27.0?758.6; P<0.05).
Conclusion: Opioid prescriptions substantially increased, regardless of the cancer diagnosis, over the study period. This may imply that awareness of active pain control has improved in Korea.
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KEYWORD
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Analgesics, opioid, Epidemiology, Pain, Neoplasms
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